All women with pathologically documented ovarian, fallopian tube, or primary peritoneal cancer treated with carboplatin alone or a carboplatin-based combination chemotherapy regimen at a single hospital between January 2006 and December 2013 were retrospectively recruited. The ESMO Clinical Practice Guidelines (CPGs) are intended to provide the user with a set of recommendations for the best standards of cancer care, based on the findings of evidence-based medicine. The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Algorithm for the evaluation of drug hypersensitivity reactions and the role of desensitization for the re-introduction of the first-line medications, when no alternative is available or the alternative does not provide the same benefits or life expectancy as the first line. Efficacy and Adverse Events of Carboplatin Desensitisation Therapy for Gynaecological Cancer: A Retrospective Study. Zhonghua. Unauthorized use of these marks is strictly prohibited. One patient who experienced a carboplatin-related hypersensitivity reaction progressed to respiratory arrest and died. Allergic and non-allergic ovarian cancer patients treated with carboplatin or carboplatin desensitization presented a similar life expectancy with a non significant advantage for the allergy desensitized patients. Front Oncol. This exciting partnership delivered a unique cancer congress in Europe with huge scientific reach and the true potential to improve the lives of cancer patients. Study conception and design: Y-HT and W-FC. Cancer 15, 1318. J. Clin. 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(2005). In the US, PH FDC SC can be administered by healthcare professionals in patients (pts) homes. Tyler T, Schultz A, Venturini A, Giuliano C, Bernareggi A, Spezia R, Voisin D, Stella V. Clin Pharmacol Drug Dev. Close monitoring is warranted for patients with any one of these three risk factors who are receiving carboplatin. In our study, 36% of the patients with carboplatin-related hypersensitivity reactions had a history of drug allergies. Gerber, C. van den Hurk, P. Fernndez-Peas, D. Santini, F. Jahn, K. Jordanon behalf of the ESMO Guidelines Committee. doi: 10.1200/JOP.18.00761. 2011 Aug;12(8):806-14. doi: 10.1016/S1470-2045(10)70208-4. Copyright 2017 Tai, Tai, Hsu, Lee, Chen, Chiang, Chen, Chen and Cheng. Request PDF | On Jul 13, 2017, Susana Rosell Kernen published Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines | Find, read and cite all the . The ESMO Clinical Practice Guidelines, prepared and reviewed by leading experts and based on the findings of evidence-based medicine, provide you with a set of recommendations to help patients with the best care options. This review provides insight into the current knowledge of drug allergy and anaphylaxis to cancer and chronic inflammatory diseases drugs, the mechanisms of drug desensitization and its applications to personalized medicine. Ann Oncol. For more detailed information on the cookies we use, please check our Privacy Policy. official website and that any information you provide is encrypted Prevention and Management of Dermatological Toxicities Related to Anticancer Agents: ESMO Clinical Practice Guidelines. Rosell S, Blasco I, Garca Fabregat L, Cervantes A, Jordan K; ESMO Guidelines Committee. Cisplatinum rechallenge in relapsed ovarian cancer patients with platinum reinduction therapy and carboplatin hypersensitivity. Carboplatin rechallenge after hypersensitivity reactions in pediatric patients with low-grade glioma. 4 - 9 Without premedication, hypersensitivity reactions (HSRs) occurred in 25%-30% of patients in these studies and clinical development of paclitaxel was consequently delayed. Clinical Practice Guidelines on Supportive Care - ESMO Management of toxicities from immunotherapy: ESMO Clinical Practice Symptoms and signs of 75 patients with hypersensitivity reactions to carboplatin. 2018 Jun;54(3):375-385. doi: 10.1007/s12016-016-8556-5. Cancer 109, 10721078. doi: 10.1016/j.ygyno.2007.06.016, Markman, M., Kennedy, A., Webster, K., Elson, P., Peterson, G., Kulp, B., et al. Abstracts, slide sets and webcasts from ESMO 2017 Congress are now available. Patients with prior drug or food allergies should be closely monitored during carboplatin administration. ESMO Call to Action on COVID-19 Vaccinations and Patients with Cancer: Vaccinate. Nektaria M, Ekaterini S, Ioannis K, Leonidas M, Muhammad Wasif S. Hypersensitivity reactions associated with platinum antineoplastic agents: a systematic review. -. Information for media including press accreditation. Women are more affected by drug allergy and up to 27% of women with ovarian and breast cancer develop carboplatin allergy after multiple cycles of treatment. Incidence of carboplatin-related hypersensitivity reactions in Japanese patients with gynecologic malignancies. Multivariate analyses of clinical parameters for carboplatin-related hypersensitivity reactions. Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. However, 48 (78.7%) of these patients developed repeated hypersensitivity reactions, even after pre-treatment with intravenous antihistamines, H2 blocker, and corticosteroids prior to carboplatin re-administration. All funding for this site is provided directly by ESMO. Create your own personalised agenda and browse the complete scientific programme by day, topic, cancer type and track with the ESMO events app. Please enable it to take advantage of the complete set of features! Careers. The median patient age was 56 years (range 1694 years). National Library of Medicine All the statistical tests were two-tailed, and statistical significant level was defined as p-value < 0.05. In conclusion, in our present population of women with gynecological malignancies treated with platinum-based chemotherapy, 1 in 10 developed carboplatin-related hypersensitivity reactions. Analysis and interpretation of data: Y-HT, Y-JT, H-CH, Y-YC, and W-FC. European Hematology Association (EHA) and European . J Exp Clin Cancer Res (2011) 30:93.10.1186/1756-9966-30-93 These risk factors can help identify patients at greater risk of developing hypersensitivity. All funding for this site is provided directly by ESMO. Login to your ESMO accountto sign up for ESMO newsletters and receive information about ESMO's scientific and educational resources, events, member benefits. Epub 2019 Jul 3. 17, 11411145. Allergy in Cancer Care: Antineoplastic Therapy-Induced Hypersensitivity Reactions. Tumori 89, 311313. Login to your ESMO account to sign up for ESMO newsletters and receive information about ESMO's scientific and educational resources, events, member benefits. Published in 2020 - Ann Oncol (2020) Authors: M.E. PH IV/PH FDC SC is standard of care for HER2-positive BC and usually given with chemotherapy, all of which can trigger anaphylaxis/hypersensitivity. Furthermore, patients with carboplatin hypersensitivity had a higher incidence of previous allergic history to other cytotoxic drugs, including gemcitabine, paclitaxel, and doxorubicin, compared to those without (12/75 vs. 30/660, P < 0.001, chi-squared test; Table 7). Doxorubicin/adriamycin and other chemotherapies present with sudden onset hypo or hypertension in up to 60% of patients and rituximab and other monoclonal antibodies present with cutaneous and cardiovascular symptoms in 70% of the patients. Does the platinum-free interval predict the incidence or severity of hypersensitivity reactions to carboplatin? We retrospectively recruited all women with pathologically documented ovarian, fallopian tube, or primary peritoneal cancer treated with single-agent carboplatin or a carboplatin-based combination chemotherapy regimen at National Taiwan University Hospital from January 2006 to December 2013. Death from anaphylaxis to cisplatin: a case report. In 74 of the 75 patients, the hypersensitivity reactions subsided within several minutes to several hours after onset, and the patients recovered without any sequelae. Multivariate analysis was conducted using logistic regression to estimate the association between the potential risk factors and the occurrence of hypersensitivity. J Investig Allergol Clin Immunol. Only 2 women are Mongolians and the other 733 women are Asian Taiwanese. Reducing the carboplatin infusion rate and employing desensitization protocols with anti-allergy medications are especially important for patients at high risk of carboplatin hypersensitivity to detect the hypersensitivity early and avoid severe hypersensitivity without compromising the efficacy of the antineoplastic regimen. The most commonly exhibited symptom/sign was hypotension (10.7%), followed by anaphylaxis (8.0%) and desaturation (6.7%). Desensitization for hypersensitivity reactions to medications. The site is secure. To assist those using and/or evaluating the ESMO Guidelines, download the methodology here, Download the new version of our App with the latest Pocket Guidelines for oncology professionals. Cancer. Gynecol. Epub 2019 Mar 8. 105, 14721479. J. Clin. Drug allergy is a rising problem in the twenty-first century which affects all populations and races, children, and adults, and for which the recognition, diagnosis, management, and treatment is still not well standardized. Carboplatin hypersensitivity: does introduction of skin test and desensitization reliably predict and avoid the problem? Carboplatin hypersensitivity. (2010). and transmitted securely. Severe carboplatin-related hypersensitivity reactions are uncommon. J. ESMO is a Swiss-registered not-for-profit organisation. Carboplatin induces DNA double strand breaks, which are repaired by BRCA recombination repair enzymes. Emetogenicity of Chemotherapy : MASCC/ESMO Guidelines - EMJ Careers. J. Gynecol. Classical and new chemotherapy drugs, monoclonal antibodies (MoAbs), and small molecules to treat cancer and chronic inflammatory diseases are aimed at improving quality of life and life expectancy of patients, but an increasing number of reactions including anaphylaxis precludes their use in targeted populations. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. With a lower carboplatin infusion rate and pre-treatment with anti-allergy drugs, all of these patients were able to tolerate re-treatment with carboplatin, although 48 (78.7%) of these 61 patients developed hypersensitivity again despite the desensitization protocol. The annual incidence of carboplatin-related hypersensitivity reactions in 735 women with ovarian, fallopian tube, or primary peritoneal cancers. Cisplatin administration following carboplatin desensitization failure in primary peritoneal cancer: a brief report. However, other studies have reported severe hypersensitivity reactions to cisplatin in patients with prior carboplatin hypersensitivity reactions (Zweizig et al., 1994; Dizon et al., 2002). We performed tests on occupational exposure (from 10 different health care surfaces) from three types of chemotherapy (Cyclophosphamide, Gemcitabine and Fluorouracil) from three different hospitals in Sweden. Successful carboplatin desensitization in patients with proven carboplatin allergy. Putative mechanism of protection against anaphylaxis during human desensitizations. DARMSTADT, Germany, August 31, 2017 /PRNewswire/ --Not intended for UK-based media Data to showcase Merck KGaA, Darmstadt, Germany's strong and d. This site uses cookies. Close monitoring is warranted for patients with a history of drug or food allergy, malignant ascites, or cumulative carboplatin dose >4,000 mg. Strategies for preventing carboplatin-related hypersensitivity include reducing the carboplatin infusion rate and employing desensitization protocols with anti-allergy medications. Here's a summary of the new ESMO guidelines in 5 key areas: . Gynecol. Supportive and palliative care are areas of high importance in oncology and ESMO published Clinical Practice Guidelines on the management of a variety of issues: Palliative Care in the COVID-19 era, Advanced Care Planning, Anaemia and Iron Deficiency in Patients With Cancer, Anxiety and Depression,Bone Health in Cancer Patients, Cancer Cachexia in Adult Patients, Cancer Pain, Cancer-related Fatigue,Care at the End of Life, Central Venous Access in Oncology, Chemotherapy Extravasation, Constipation in Advanced Cancer, Delirium in Adult Cancer Patients,Diarrhoea in Adult Cancer Patients, Infusion Reactions to Systemic Anticancer TherapyFebrile Neutropaenia, Fertility Preservation and Post-treatment Pregnancies in Post-pubertal Cancer Patients, Management of Breathlessness in Patients with Cancer,Management of Cardiac Disease, Management of Orphan Symptoms, Neurotoxicity,Oral and Gastrointestinal Mucosal Injury, Prevention and Management of Dermatological Toxicities Related to Anticancer Agents, Prevention of Chemotherapy and Radiotherapy-Induced Nausea and Vomiting, Prognostic Evaluation in Advanced Cancer,Role of Patient-reported Outcome Measures, Toxicities from immunotherapy and Venous Thromboembolism in Cancer Patients. 2017 Jul 1;28(suppl_4):iv100-iv118. Lancet 361, 20992106. Allergy Asthma Proc (2011) 32(1):79.10.2500/aap.2011.32.3409 Drug Interactions in the Treatment of Malignancy in HIV-Infected Patients. II., Markman, M., Brown, J., et al. (2012) demonstrated that carboplatin treatment can be continued successfully in patients whose hypersensitivity reactions are managed in a timely fashion. Platinum desensitization in patients with carboplatin hypersensitivity: a single-institution retrospective study. It didn't disappoint. Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Have a look to the ESMO 2017 Programme online! Authors: S. Rosell, I. Blasco, L. Garca Fabregat, A. Cervantes and K. Jordan Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. EHA Endorsement of ESMO Clinical Practice Guidelines for Diagnosis, Treatment, and Follow-up for Myelodysplastic Syndromes. Trends in incidence and survival outcome of epithelial ovarian cancer: 30-year national population-based registry in Taiwan. Do Steroids Matter? A Retrospective Review of Premedication for Taxane doi: 10.1159/000055363, Pujade-Lauraine, E., Wagner, U., Aavall-Lundqvist, E., Gebski, V., Heywood, M., Vasey, P. A., et al. Oncol. Before Recommendations for prevention/therapy of acneiform rash, hand-foot syndrome, alopecia, pruritus, paronychia and onycholysis are provided including levels of evidence and grades of recommendation where applicable. A cumulative carboplatin dose >4,000 mg significantly positively correlated with carboplatin hypersensitivity. Borrs Cuartero J, Farzanegan Miano R, Torres Gorriz MC, Germn Snchez A, Aznar RC, Raducan I, Castell Carrascosa JV, Sanchez Hernandez A, Enrique E. Front Allergy. The site is secure. ESMO Virtual Congress 2020 | OncologyPRO Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. Management of infusion reactions to systemic anticancer therapy: ESMO 2022 Apr 26;14(4):e24515. ESMO 2017 was held in partnership with the European Association for Cancer Research (EACR) in Madrid . ESMO is a Swiss-registered not-for-profit organisation. Table 5. http://downloads.hindawi.com/journals/mbd/2010/207084.pdf, Kadoyama K, Kuwahara A, Yamamori M, Brown JB, Sakaeda T, Okuno Y. Hypersensitivity reactions to anticancer agents: data mining of the public version of the FDA adverse event reporting system, AERS. (2001). Carriers of BRCA genes develop drug allergy after fewer exposures and can present with severe reactions, including anaphylaxis. The ESMOClinical Practice Guidelines(CPGs) are intended to provide the user with a set of recommendations for the best standards of cancer care, based on the findings ofevidence-based medicine. Thus, we chose the cumulative carboplatin dose for the analysis to avoid interference between the highly correlated factors. View the photographic highlights from ESMO 2017 here! Atopic patients are at increased risk for chemotherapy and MoAbs drug allergy and the current patterns of treatment with recurrent and intermittent drug exposures may favor the development of drug allergies. 2017 Jun 20;18(6):1316. doi: 10.3390/ijms18061316. Among 735 eligible women, 75 (10.2%) experienced a total of 215 carboplatin-related hypersensitivity reaction events. government site. The MASCC/ESMO guidelines recommend that patients receiving HEC are given a dose of 20 mg dexamethasone on Day 1 to prevent acute emesis; however, if the NK 1 RAs aprepitant or netupitant are also used, a reduced dose of 12 mg dexamethasone is recommended. Ann. doi: 10.1111/IGC.0b013e3181a418ff, Greene, D. P., Ferriss, J. S., and Jazaeri, A. Menu icon A vertical stack of three evenly . S M S, Naveen NR, Rao GK, Gopan G, Chopra H, Park MN, Alshahrani MM, Jose J, Emran TB, Kim B. Oncol. We also found higher rates of hypersensitivity among patients with malignant ascites compared to patients without malignant ascites (P = 0.009, chi-squared test), and in patients who had experienced allergic reactions to other medications or food (e.g., paclitaxel, penicillin, aspirin) compared to patients who had not experienced previous allergic reactions (P < 0.001, chi-squared test). Int. Integrating science into oncology for a better patient outcome, ESMO Designated Centres Community Session, Create your own personalised agenda and browse the complete scientific programme by day, topic, cancer type and track with the. National Library of Medicine A., Colombo, N., du Bois, A., Delaloye, J. F., Kristensen, G. B., et al. doi: 10.1111/j.1525-1438.2007.01063.x, Genc, D. B., Canpolat, C., and Berrak, S. G. (2012). Morgan C, Tillett T, Braybrooke J, Ajithkumar T. Lancet Oncol. Challenges in the Development of Intravenous Neurokinin-1 Receptor Antagonists: Results of a Safety and Pharmacokinetics Dose-Finding, Phase1 Study of Intravenous Fosnetupitant.
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